Yes, as it has for me and so many other people. Please remember, your cells have memory. This is important. For example to have an immune system we need cell memory. To know which foods you like and don't like, it also involves cell memory. So, I urge people not to beat themselves up thinking that I simply have to stop eating such and such an item. Rather, and isn't it more appealing to be able to voluntarily control how much you eat so that the volume, and calories are greatly reduce, but occasionally the pleasure is still there? So while I don't need to lose weight, I periodically take leptin at those times when I know that cravings might get stronger than they should.